EC Number   |
Natural Substrates |
|---|
   3.4.24.69 | 25 kDa synaptosome-associated protein + H2O |
- |
| 3.4.24.69 | 25-kDa synaptosome-associated protein + H2O |
i.e. SNAP-25 |
| 3.4.24.69 | Ac-SNKTIDEANQRATKML-NH2 + H2O |
synaptosomal protein |
| 3.4.24.69 | cytosolic SNARE + H2O |
host cytosolic SNARE, i.e. soluble NSF attachment protein receptor, a central helical protein-conducting channel, which chaperones the protease across host endosomes, modelling, overview. Sequence-specific claveage by the endoprotease activity of the BoNT light chains |
| 3.4.24.69 | membrane-anchored SNARE + H2O |
host membrane-anchored SNARE, proteolytically cleaved by BoNT/C |
| 3.4.24.69 | more |
able to cleave selectively an essential component of neurotransmitter exocytosis, causing the syndrome of botulism characterized by flaccid paralysis |
| 3.4.24.69 | more |
most potent neurotoxin known |
| 3.4.24.69 | more |
most potent toxin known |
| 3.4.24.69 | more |
only mammalian proteins, SNAP-25 from Drosophila sp. and Torpedo sp. are no substrates |
| 3.4.24.69 | more |
undergoes autocatalytic proteolytic processing and fragmentation |
