EC Number   |
Natural Substrates |
|---|
   3.4.24.22 | ADAMTS-like protein 1 + H2O |
i.e. punctin-1, an extracellular matrix protein. cooperative processing of ADAMTSL1 by both MMP10 and MMP2, EC 3.4.24.24 |
| 3.4.24.22 | Fibronectin + H2O |
- |
| 3.4.24.22 | more |
participates in activation of procollagenase proMMP-1 |
| 3.4.24.22 | more |
expression of the collagenase gene family, of which the stromelysin-2 gene is one, might play a role in cancer |
| 3.4.24.22 | more |
expression of transin and transin-2 in tumor cells might play a role in tumor invasion |
| 3.4.24.22 | more |
cells resistant to protein kinase C potentiated, transcription factor p53 mediated apoptosis express a higher level of matrix metalloproteinases MMP-9 and MMP-10. Matrix metalloproteinases function confers protection from protein kinase C/p53 induced apoptosis and are implicated in tumor cell resistance |
| 3.4.24.22 | more |
enzyme is involved in intestinal re-epithelialization in vivo and up-regulated by cytokines involved in wound repair |
| 3.4.24.22 | more |
matrix metalloproteinase MMP-1 zymogen activation by enzyme and other serine proteases is central to endothelial cell-mediated collagen degradation and capillary tube regression in 3D collagen matrices |
| 3.4.24.22 | more |
active MMP-10 does not cleave collagen type 1 directly, it does activate the collagenase MMP-1, EC 3.4.24.7. The ability of active MMP-10 to superactivate MMP-1 creates a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation |
| 3.4.24.22 | more |
MMP-10 is a potent activator of a number of MMP pro-enzymes, including pro-MMP-1, -7, -8, -9 and -13 |
