EC Number   |
Natural Substrates |
|---|
   3.4.23.B4 | feline apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 protein + H2O |
APOBEC3, FIV protease cleaves feline APOBEC3, A3Z2Z3, in released virions. The leucine residue at position 232 of feline A3Z2Z3 is related to cleavage by FIV PR |
| 3.4.23.B4 | Gag-Pol polyprotein + H2O |
processing of the precursor protein |
| 3.4.23.B4 | Gag-Pol polyprotein + H2O |
processing of the precursor protein into several mature proteins |
| 3.4.23.B4 | Gag-Pol polyprotein + H2O |
FIV PR cleaves Gag polyprotein into 5 individual proteins, including matrix, capsid, p1, nucleocapsid, and p2 |
| 3.4.23.B4 | Gag-Pol polyprotein + H2O |
the Gag precursor is cleaved into the final mature Gag proteins matrix, capsid, nucleocapsid, spacer peptides (SP1, SP2), flanking nucleocapsid, and the C-terminal peptide p2 |
| 3.4.23.B4 | more |
the enzyme is essential for virion maturation and subsequent viral replication in that it cleaves the Gag and Gag/Pol polyproteins at eight sites to release the respective structural proteins and enzymes |
| 3.4.23.B4 | more |
feline immunodeficiency virus induces neurological deficits in the central nervous system of host cats which can be prevented by treatment with the feline immunodeficiency virus protease inhibitor TL-3, overview |
| 3.4.23.B4 | more |
the enzyme performs autolytic processing of the precursor protein of which it is a part, cutting out itself and other proteins, the Gag polyprotein occurs in different splicing forms and sizes of 50-60 kDa to 150-200 kDa |
