EC Number   |
Natural Substrates |
|---|
   3.4.22.68 | more |
the enzyme is specifically required for cell cycle progression |
| 3.4.22.68 | small ubiquitin-related modifier-CENP-I + H2O |
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins |
| 3.4.22.68 | small ubiquitin-related modifier-Mdm2 + H2O |
co-localization of SENP2 with SUMO conjugated Mdm2. SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies |
| 3.4.22.68 | small ubiquitin-related modifier-protein + H2O |
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins |
| 3.4.22.68 | SMT3precursor + H2O |
- |
| 3.4.22.68 | SUMO-1 protein + H2O |
- |
| 3.4.22.68 | SUMO-1 protein + H2O |
Ulp1 catalyzes two essential functions in the SUMO pathway: 1. the processing of full-length SUMO to its mature form and 2. deconjugation of SUMO from target proteins. Ulp1 can proteolyze large folded SUMO-conjugated proteins without altering their structure |
| 3.4.22.68 | SUMO-1 protein + H2O |
the enzyme plays an essential role in the G2/M phase of the cell cycle |
