EC Number |
Natural Substrates |
---|
3.4.22.61 | alpha-fodrin + H2O |
- |
3.4.22.61 | Atg3 protein + H2O |
- |
3.4.22.61 | BH3-only protein Bid + H2O |
- |
3.4.22.61 | BID + H2O |
a 15000 Da C-terminal frament and a 14000 Da N-terminal fragment are generated by caspase-8 cleavage at T58-/-D59. While full-length BID is localized in cytosol, truncated BID translocates to mitochondria and thus transduces apoptotic signals from cytoplasmic membrane to mitochondria. BID is a mediator of mitochondrial damage induced by Casp8 |
3.4.22.61 | Bid + H2O |
Bid is a caspase-8 substrate and that its cleavage can be crucial for CD95-induced apoptosis. Caspase-8-mediated cleavage of Bid into a pro-apoptotically active, truncated form provides the link between death receptor stimulation and mitochondrial apoptotic events |
3.4.22.61 | Bid + H2O |
i.e. BH3 interacting domain death agonist |
3.4.22.61 | Bid peptide + H2O |
- |
3.4.22.61 | Bid peptide + H2O |
a specific caspase-8 substrate |
3.4.22.61 | Bid peptide + H2O |
CTX III, from crude venom of Naja naja atra, inhibits proliferation of human leukemia K562 cells by G2/M phase arresting and apoptosis which is associated with the activation of caspase-8 and cytochrome c release as well as the p38 and c-Jun N-terminal protein kinase phosphorylation signaling pathway in vitro and in vivo, caspase-8-dependent Bid-Bax pathway, overview |
3.4.22.61 | Bid protein + H2O |
- |