EC Number   |
Natural Substrates |
|---|
   3.4.22.60 | 26S proteasome subunit + H2O |
during apoptosis, the activated caspase-7 directly cleaves certain subunits of 26S proteasomes, which then result in a decline in the proteasomal activity |
| 3.4.22.60 | acid sphingomyelinase + H2O |
caspase-7 activates acid sphingomyelinase induced by TNF, overview. Generation of the active 57 kDa fragment of endogenous A-SMase in wild-type HeLa cells. Direct association of caspase-7 and A-SMase within TNF receptosomes |
| 3.4.22.60 | actin-related protein 2/3 complex subunit 3 + H2O |
- |
| 3.4.22.60 | ataxin-7 + H2O |
ataxin-7 is cleaved by caspase-7, cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein. Proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis |
| 3.4.22.60 | caspase-7 biosensor vDEVDc + H2O |
wild-type caspase-7 binds to caspase-7 biosensor vDEVDc, but does not cleave it, while an mutant isozymes of caspase-7 with the 24 or 56 N-terminal residues truncated, i.e. 24casp7 and 57casp7, respectively, cleave vDEVDc at the recognition sequence |
| 3.4.22.60 | epidermal growth factor receptor + H2O |
cleavage during apoptosis |
| 3.4.22.60 | far upstream element binding protein 1 + H2O |
- |
| 3.4.22.60 | FK506-binding protein 4 + H2O |
- |
| 3.4.22.60 | fructose-bisphosphate aldolase A + H2O |
- |
| 3.4.22.60 | gamma-actin + H2O |
- |
