EC Number   |
Natural Substrates |
|---|
   3.4.22.57 | LEVD-7-amido-4-trifluoromethylcoumarin + H2O |
- |
| 3.4.22.57 | more |
the enzyme is involved in cytokine activation |
| 3.4.22.57 | more |
the production of the enzyme induces activation of CPP32 like caspase |
| 3.4.22.57 | more |
overexpression of ICH-2 in insect cell induces apoptosis |
| 3.4.22.57 | more |
the enzyme is capable of inducing apoptosis in transfected cells such as fibroblasts and may play a role in apoptotic cell death |
| 3.4.22.57 | more |
overexpression of the enzyme induces apoptosis |
| 3.4.22.57 | more |
caspase-4 can function as an ER-stress-specific caspase in humans, and may be involved in pathogenesis of Alzheimer's disease |
| 3.4.22.57 | more |
protective role of CARD only protein in Rip2/caspase-1/caspase-4-mediated HeLa cell death. CARD only protein binds and inhibits caspase-4 activation |
| 3.4.22.57 | more |
familial Alzheimer's disease-linked presenilin-1 mutation accelerates the cleavage of caspase-4 under the endoplasmic reticulum stress and results in the activation of caspase-9 and caspase-3, apoptosis signal, without releasing cytochrome-c |
| 3.4.22.57 | more |
misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms |
