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Results 1 - 10 of 63

EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.4.22.53	alpha-2 spectrin + H2O	-
3.4.22.53	alpha-spectrin + H2O	-
3.4.22.53	aminopeptidase B + H2O	-
3.4.22.53	androgen receptor + H2O	-
3.4.22.53	beta-transducin repeat containing protein + H2O	-
3.4.22.53	calmodulin-dependent protein kinase II deltaB + H2O	angiotensin II enhances the interaction between activated calpain-2 and Ca2+/calmodulin-dependent protein kinase II deltaB (CaMKIIdB), and promotes the degradation of CaMKIIdB by calpain-2 in the nuclei of hypertrophied cardiomyocytes. The depressed CaMKIIdeltaB downregulates the expression of antiapoptotic Bcl-2 leading to mitochondrial depolarization and release of cytochrome c which leads to apoptosis of hypertrophied cardiomyocytes
3.4.22.53	casein + H2O	-
3.4.22.53	caspase-3 + H2O	-
3.4.22.53	collapsin response mediator protein-1 + H2O	collapsin response mediator protein-1 is cleaved by calpain-2 at the C-terminus
3.4.22.53	collapsin response mediator protein-2 + H2O	collapsin response mediator protein-2 is cleaved by calpain-2 at the C-terminus

Results 1 - 10 of 63

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Release 2023.1 (January 2023)