EC Number   |
Natural Substrates |
|---|
   3.4.22.37 | apoB-100 protein + H2O |
apoB-100 degradation induces LDL-modification and contributes to the onset of atherosclerosis |
| 3.4.22.37 | C3 protein + H2O |
- |
| 3.4.22.37 | C4 protein + H2O |
- |
| 3.4.22.37 | C5 protein + H2O |
at higher enzyme concentrations |
| 3.4.22.37 | CD27 protein + H2O |
involved in reduction of T-cell function, effective even in the presence of 2.5 or 5% serum |
| 3.4.22.37 | cell adhesion molecule + H2O |
involved in the detachment of endothelial cells |
| 3.4.22.37 | Collagen type I + H2O |
not the purified isoforms, enzyme probably needs to be attached to the cell surface |
| 3.4.22.37 | CXCL8 + H2O |
- |
| 3.4.22.37 | elafin + H2O |
all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) |
| 3.4.22.37 | elafin + H2O |
all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) with RgpB being far more efficient than other gingipains. RgpB efficiently inactivates the inhibitory activity of elafin at subnanomolar concentrations through proteolysis limited to the Arg22-Cys23 peptide bond within the surface loop harboring the inhibitor active site |
