EC Number |
Natural Substrates |
---|
3.4.22.1 | amyloid beta peptide + H2O |
cathepsin B is involved in degradation of amyloid beta peptides, its inhibition can lead to amyloid beta accumulation, an early trigger of Alzheimer's disease, cystatin C regulates the enzyme negatively, CysC ablation ameliorates amyloid beta-associated neuronal and synaptic deficits in hippocampal circuits, neuroprotective effects of CysC ablation depend on CatB, overview |
3.4.22.1 | amyloid beta precursor protein + H2O |
cathepsin B selectively cleaves the wild-type beta-secretase site but not the rare Swedish mutant beta-secretase site |
3.4.22.1 | amyloid-beta + H2O |
- |
3.4.22.1 | caspase 1 precursor + H2O |
- |
3.4.22.1 | Collagen + H2O |
- |
3.4.22.1 | Collagen IV + H2O |
- |
3.4.22.1 | Collagen IV + H2O |
collagen IV of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview |
3.4.22.1 | Gelatin + H2O |
- |
3.4.22.1 | Laminin + H2O |
laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview |
3.4.22.1 | more |
enzyme is involved in myoblast-myoblast fusion |