EC Number   |
Natural Substrates |
|---|
   3.4.21.B25 | CLIP protein + H2O |
- |
| 3.4.21.B25 | human immunodeficiency virus type 1 Vpr + H2O |
undergoes proteolytic processing at a very well conserved proprotein convertase cleavage site, R85QRR88-/-, proprotein convertases PC5 and PACE4 can efficiently process extracellular Vpr |
| 3.4.21.B25 | insulin receptor isoform B zymogen + H2O |
maturation |
| 3.4.21.B25 | more |
enzyme binds tightly to heparin and anchors heparan sulfate proteoglycans at the extracellular matrix, role in spatiotemporal regulation of TGFbeta-related factors' biological activity |
| 3.4.21.B25 | more |
role in proteolytic activation of anthrax toxin PA |
| 3.4.21.B25 | more |
PACE4 is identified as a proprotein convertase responsible for activation of aggrecanases in osteoarthritic and cytokine-stimulated cartilage |
| 3.4.21.B25 | preprohepcidin + H2O |
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin |
| 3.4.21.B25 | pro-branching morphogenesis protein 2 + H2O |
- |
| 3.4.21.B25 | pro-complement C3 + H2O |
- |
| 3.4.21.B25 | pro-Nodal + H2O |
- |
