EC Number   |
Natural Substrates |
|---|
   3.4.21.B24 | more |
PCSK4 appears to be a crucial enzyme for reproduction |
| 3.4.21.B24 | more |
members of the ADAM family, in particular ADAM1 or fertilin alpha, ADAM2 or fertilin beta, and ADAM3 or cyritestin, are potential substrates for PCSK4. ADAMs are biosynthesized in male germ cells as type-1 transmembrane precursor proteins and undergo a cascade of testicular and post-testicular proteolytic cleavages to their acrosomebound forms |
| 3.4.21.B24 | more |
PC4 substrates are growth factors proIGF-1 and proIGF-2, hormonal polypeptides, proPACAP, and surface proteins of the ADAM family, e.g. ADAM1 or fertilin alpha, ADAM2 or fertilin beta, ADAM3 or cyritestin, and ADAM5 |
| 3.4.21.B24 | more |
proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells |
| 3.4.21.B24 | pro-insulin growth factor + H2O |
- |
| 3.4.21.B24 | proform acrosin-binding protein + H2O |
a sperm fertilization molecule located in the acrosomal matrix, the enzyme activates the substrate by processing from a 58.5 kDa precursor to a 27.5 kDa mature form |
| 3.4.21.B24 | proform IGF-2 + H2O |
- |
