EC Number   |
Natural Substrates |
|---|
   3.4.21.94 | more |
present on secretory pathway of neuroendocrine cells |
| 3.4.21.94 | more |
processing of precursors that are routed toward secretory granules |
| 3.4.21.94 | more |
glucose-dependent insulinotropic polypeptide precursor is no substrate of PC2 |
| 3.4.21.94 | more |
proprotein convertases play a major role in liver metastasis |
| 3.4.21.94 | pro-cholecystokinin + H2O |
the substrate is only cleaved in vivo since defolding proteins are required, in vitro the cleavage site is inaccessible for the enzyme |
| 3.4.21.94 | pro-islet amyloid polypeptide + H2O |
precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the N-terminus, but not the C-terminus, which would also be required for activation, the complete activation is catalyzed by PC1, EC 3.4.21.93 |
| 3.4.21.94 | proenkephalin + H2O |
- |
| 3.4.21.94 | proenkephalin + H2O |
cleaves prohormones and proneuropeptides from inactive large precursors to generate activre peptide for extracellular release |
| 3.4.21.94 | Proglucagon + H2O |
- |
| 3.4.21.94 | Proglucagon + H2O |
key endoprotease responsible for proglucagon processing in cells with the alpha-cell phenotype |
