EC Number   |
Natural Substrates |
|---|
   3.4.21.75 | ADAMTS9 propeptide + H2O |
the intact zymogen is secreted to the cell surface and is subsequently processed by furin before release into thge medium. ADAMTS9 processing is exclusively extracellular and occurs at the cell surface in cells that express high levels of furin |
| 3.4.21.75 | DSSARIRRNAKG + H2O |
peptide derived bone morphogenetic protein BMP10, cleavage occurs at residue R316 |
| 3.4.21.75 | factor IX + H2O |
- |
| 3.4.21.75 | feline foamy virus Env glycoprotein precursor + H2O |
- |
| 3.4.21.75 | full-length (pro)renin receptor + H2O |
i.e. (P)RR, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A. The soluble form of the (pro)renin receptor generated through intracellular cleavage by furin is secreted in plasma |
| 3.4.21.75 | G-protein-coupled receptor GPR107 + H2O |
cleavage by endoprotease furin, a disulfide bond connects the two resulting fragments, overview |
| 3.4.21.75 | HIV-1 Tat protein + H2O |
furin processing is a likely mechanism for inactivating extracellular HIV-1 Tat protein. Furin cleavage reduces the transactivation activity of tat without preventing Tat uptake and entry into the nucleus |
| 3.4.21.75 | human semaphorin 3F + H2O |
furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin, overview |
| 3.4.21.75 | IBV spike protein + H2O |
- |
| 3.4.21.75 | insulin-like growth factor-1 receptor + H2O |
furin-like proprotein convertase activates insulin-like growth factor-1 receptor in vascular smooth muscle cell |
