EC Number   |
Natural Substrates |
|---|
   3.4.21.69 | active factor Va + H2O |
proteolytic inactivation |
| 3.4.21.69 | active factor Va + H2O |
proteolytic inactivation of the cofactor in the prothrombinase complex |
| 3.4.21.69 | active factor Va + H2O |
activated protein C inhibits the procoagulant function of activated factor V through proteolytic cleavage |
| 3.4.21.69 | active factor Va + H2O |
proteolytic inactivation requires interactions with both EPCR and PAR-1 |
| 3.4.21.69 | active factor VIII + H2O |
activated protein C and activated factor X play a role in proteolytic inactivation of activated coagulation factor VIII involving the B domain, the inactivated substrate factor VIII is less efficient on blood clotting, overview |
| 3.4.21.69 | active factor VIIIa + H2O |
proteolytic inactivation |
| 3.4.21.69 | active factor VIIIa + H2O |
the inactivation of factor VIIIa by the enzyme is responsible for its high anticoagulation effect, high factor VIII contents lead to increased resistance to activated protein C, while factor II and factor X are not correleted to active protein C resistance, mechanism, overview |
| 3.4.21.69 | factor V + H2O |
proteolytic inactivation |
| 3.4.21.69 | Factor Va + H2O |
- |
| 3.4.21.69 | Factor Va + H2O |
natural anticoagulant, inhibits thrombin generation by degrading factors Va and VIIIa |
