EC Number   |
Natural Substrates |
|---|
   3.4.21.45 | complement component C3(NH3) + H2O |
cleaved by SP domain-form |
| 3.4.21.45 | complement component C3b + H2O |
- |
| 3.4.21.45 | complement component C3b + H2O |
mutation of complement factor I associated to atypical hemolytic uremic syndrome analyzed, activity observed in mutant protein comparable to wild-type |
| 3.4.21.45 | complement component C3b + H2O |
the complement C3 fragments C3b and iC3b appear on the surface of several virulent Staphylococcus aureus strains of capsule polysaccharide type 5 and 8. Factor I mediates the cleavage of C3b to iC3b on the surface of Staphylococcus aureus and appears to be able to function without the serum cofactor, factor H |
| 3.4.21.45 | complement component C3b + H2O |
cleavage at five different sites in the alpha-chain, generating complement component C3d.g-like fragments with three different N-terminal and two different C-terminal ends |
| 3.4.21.45 | complement component C3b + H2O |
cleavage of three peptide bonds in the alpha chain of complement component C3b, thereby inactivating this protein |
| 3.4.21.45 | complement component C3b + H2O |
enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha-chains of complement component C4b and complement component C4b |
| 3.4.21.45 | complement component C3b + H2O |
degradation in presence of C4b binding protein and factor H |
| 3.4.21.45 | complement component C3bi + H2O |
the breakdown of human erythrocyte-bound C3bi molecules in serum or plasma is mediated only by factor I |
| 3.4.21.45 | complement component C4b + H2O |
- |
