EC Number   |
Natural Substrates |
|---|
   3.4.21.38 | factor VII + H2O |
enzyme is involved in the blood coagulation cascade |
| 3.4.21.38 | factor XI + H2O |
- |
| 3.4.21.38 | factor XI + H2O |
enzyme is involved in the blood coagulation cascade |
| 3.4.21.38 | more |
participation of the Hageman factor-dependent system in the inflammatory response to pseudomonal infections, due to the initiation of the system by bacterial elastase |
| 3.4.21.38 | more |
increased levels of activated coagulation factor XIIa are associated with coronary heart disease, sepsis, and diabetes |
| 3.4.21.38 | more |
enzyme contributes to pathologic clotting through the intrinsic pathway |
| 3.4.21.38 | more |
roles of enzyme as a modulator of cellular adhesion, migration and vascularization |
| 3.4.21.38 | more |
FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin |
| 3.4.21.38 | more |
FXII autoactivates by contact with a variety of artificial or biologic negatively charged surfaces (contact activation), resulting in blood coagulation and activation of the inflammatory kallikrein-kinin and complement systems |
| 3.4.21.38 | more |
FXII plays a functional role in thrombus formation and stabilization during stroke, FXII is an essential component of pathologic thrombus formation but not of physiologic hemostasis |
