EC Number   |
Natural Substrates |
|---|
   3.4.21.35 | epithelial sodium channel + H2O |
- |
| 3.4.21.35 | insulin-like growth factor binding proteins |
i.e. IGFBP |
| 3.4.21.35 | insulin-like growth factor binding proteins |
degradation of IGFBP 2-5 |
| 3.4.21.35 | insulin-like growth factor binding proteins |
enhancement of IGF bioavailability, role in tumor progression |
| 3.4.21.35 | kininogen + H2O |
- |
| 3.4.21.35 | kininogen + H2O |
important role in bradykinin release in seminal fluid |
| 3.4.21.35 | kininogen + H2O |
best substrate |
| 3.4.21.35 | kininogen + H2O |
enzyme is involved in inflammation, sepsis, pancreatitis, bone metabolism, heart disease, renal disease, and cancer through release of kallidin, i.e. Lys-bradykinin |
| 3.4.21.35 | low-molecular-weight kininogen + H2O |
- |
| 3.4.21.35 | more |
the enzyme is implicated in the pathology of various inflammatory disorders, the enzyme is an attractive target for therapeutic intervention in diseases such as asthma, pancreatitis and rheumatoid arthritis |
