EC Number   |
Natural Substrates |
|---|
   3.4.21.21 | Eph tyrosine kinase receptor EphA2 + H2O |
cleavage site at the Arg159-His160 bond |
| 3.4.21.21 | Eph tyrosine kinase receptor EphB2 + H2O |
cleavage site at the Arg159-His160 bond |
| 3.4.21.21 | factor IX + H2O |
- |
| 3.4.21.21 | factor IX + H2O |
FVIIa catalyzes activation of factor X |
| 3.4.21.21 | factor VIII + H2O |
FVIII activity increases about 4-fold within 30 s in the presence of FVIIa/tissue factor. The heavy chain of FVIII is proteolyzed at Arg336. Arg740 and Arg372 |
| 3.4.21.21 | Factor X + H2O |
- |
| 3.4.21.21 | Factor X + H2O |
the enzyme is involved in the coagulation cascade, pathways, overview |
| 3.4.21.21 | Factor X + H2O |
FVIIa catalyzes activation of factor X |
| 3.4.21.21 | factor X + H2O |
the enzyme initiates blood clotting after interacting with its cofactor tissue factor. The product of the reaction, activated factor X, is also the most efficient activator of zymogen factor VII |
| 3.4.21.21 | more |
factor VIIa initiates the coagulation pathway upon complex formation with its cellular receptor and cofactor tissue factor |
