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Results 1 - 7 of 7

EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.4.21.114	arterivirus replicase ORF1a + H2O	ORF1a can be cleaved following two alternative pathways. In the majority nsp3-8 precursors are cleaved at the nsp4/5 site yielding nsp3-4 and nsp5-8. The latter product is then cleaved at nsp7/8 only. In the alternative proteolytic cascade the nsp4/5 site remains uncleaved while the nsp5/6 and nsp6/7 sites are processed. nsp3-8 has to interact with cleaved nsp2 to allow processing of the nsp4/5 junction, when nsp2 cofactor is absent the alternative pathway is used
3.4.21.114	more	enzyme is the main viral protease
3.4.21.114	more	the enzyme controls the maturation of the replicase complex. The C-terminal domain has a modulating role in nsp4-mediated autoprocessing of the arterivirus replicase polyproteins
3.4.21.114	more	the enzyme shows a 3C-like serine protease activity
3.4.21.114	proform caspase-3 + H2O	activation
3.4.21.114	proform caspase-8 + H2O	activation
3.4.21.114	proform caspase-9 + H2O	activation

Results 1 - 7 of 7

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Release 2023.1 (January 2023)