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Results 1 - 7 of 7

EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.4.19.6	more	detection of a RNA species derived from an alternative processing at the exon 14intron 14 boundary. The alternatively processed RNA encodes a shorter version of PPII (PPII), lacking part of the C-terminal domain. PPII is expressed in COS-7 (or C6 glioma) cells but it does not exhibit any PPII activity. Co-transfection of PPII and increasing amounts of PPII* expression vectors results in a dose-dependent reduction in PPII activity and the formation of covalent PPIIPPII* heterodimers. PPII* is therefore a powerful dominant-negative isoform of PPII, and heterodimerization may be its mechanism of action. Natural expression of shortened versions of M1 aminopeptidases may constitute a new mode of regulation of their activity
3.4.19.6	thyroliberin + H2O	involved in the conversion of thyrotropin-releasing hormone into histidyl-proline diketopiperazine
3.4.19.6	thyroliberin + H2O	may control the biological activity of the neuronally released thyrotropin
3.4.19.6	thyroliberin + H2O	thyroliberin may act as neurotransmitter
3.4.19.6	thyrotrophin-releasing hormone + H2O	-
3.4.19.6	thyrotropin releasing hormone + H2O	-
3.4.19.6	TRH-like peptide + H2O	-

Results 1 - 7 of 7

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Release 2023.1 (January 2023)