EC Number |
Natural Substrates |
---|
3.4.15.1 | amyloid beta-peptide(1-40) + H2O |
cleavage at the Asp7-Ser9 bond. Compared with amyloid beta-peptide(1-40), aggregation and cytotoxic effects of the degradation products amyloid beta-peptide(1-7) and amyloid beta-peptide(8-40) are reduced ot virtually absent. The enzyme inhibits aggregation, deposition, and cytotoxicity of amyloid beta-peptide in vitro may affect susceptibility to Alzheimers disease |
3.4.15.1 | amyloid beta-protein 1-40 + H2O |
ACE cleaves amyloid beta-protein 1-40 between Asp7 and Ser8 |
3.4.15.1 | amyloid beta-protein 1-42 + H2O |
angiotensin-converting enzyme converts amyloid beta-protein 1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas.The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease |
3.4.15.1 | amyloid beta-protein 1-42 + H2O |
angiotensin-converting enzyme converts amyloid beta-protein1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas. The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease |
3.4.15.1 | amyloid beta-protein 1-42 + H2O |
ACE cleaves amyloid beta-protein 1-42 at multiple sites |
3.4.15.1 | angiotensin I + H2O |
- |
3.4.15.1 | angiotensin I + H2O |
enzyme plays a major role in blood pressure regulation |
3.4.15.1 | angiotensin I + H2O |
the enzyme plays an important role in blood pressure homeostasis |
3.4.15.1 | angiotensin I + H2O |
angiotensin II is a vasoconstrictor that raises blood pressure and is formed from angiotensin I by the angiotensin I converting enzyme in the reninangiotensin system |
3.4.15.1 | angiotensin I + H2O |
i.e. DRVYIHPFHL |