EC Number   |
Natural Substrates |
|---|
   3.4.11.3 | angiotensin III + H2O |
P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin |
| 3.4.11.3 | angiotensin III + H2O |
the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III |
| 3.4.11.3 | more |
activity is greatly increased in rats with mammary tumors. The activity may be involved in the promotion and progression of breast cancer through oxytocin, vasopressin and/or renin-angiotensin system misregulation |
| 3.4.11.3 | more |
in individuals with type 2 diabetes the insulin-stimulated translocation of IRAP to the cell-surface of muscle and fat cells is impaired. This defect may lead to decreased cleavage and consequently increased action of peptide hormones that are substrates for IRAP. Impaiered IRAP action may thus play a role in the development of complications in type 2 diabetes |
| 3.4.11.3 | more |
IRAP is required for maintenance of key constituents of endosome-derived vesicles in cardiac muscle cells |
| 3.4.11.3 | more |
the enzyme is involved in the metabolism of angiotensin |
| 3.4.11.3 | more |
the enzyme plays a role as a mediator for the effects of angiotensin IV and related peptides on extracellular dopamine levels in striatum |
| 3.4.11.3 | more |
the enzyme plays an imprtant role for IRAP in reproductive physiology in regulating the action of peptide hormones |
| 3.4.11.3 | more |
the enzyme plays diverse physiological roles in the rat central nervous system |
| 3.4.11.3 | more |
IRAP is involved in glucose transporter GLUT4 storage vesicle trafficking |
