EC Number   |
Natural Substrates |
|---|
   3.2.2.23 | 2,6-diamino-4-hydroxy-5-formamidopyrimidine-DNA + H2O |
- |
| 3.2.2.23 | 2,6-diamino-4-hydroxy-5-formamidopyrimidine:Cyt oligodeoxynucleotide + H2O |
- |
| 3.2.2.23 | 2,6-diamino-4-hydroxy-5-formamidopyrimidine:Cyt-DNA + H2O |
- |
| 3.2.2.23 | 8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide + H2O |
- |
| 3.2.2.23 | 8-oxo-7,8-dihydroguanine:Cyt-DNA + H2O |
- |
| 3.2.2.23 | DNA containing 8-oxo-2'-deoxyguanosine residues + H2O |
- |
| 3.2.2.23 | DNA containing 8-oxoguanine residues + H2O |
- |
| 3.2.2.23 | more |
8-oxo-7,8-dihydroguanine, i.e. 8-oxoGua, and 2,6-diamino-4-hydroxy-5-formamidopyrimidine, i.e. FapyGua, are premutagenic DNA lesions that appear in DNA damaged by reactive oxygen species of endogenous and environmental origin, and are excised from DNA by the enzyme. The fidelity of the 8-oxoGua repair system depends on discrimination between 8-oxoGua:Cyt and 8-oxoGua:Ade pairs by OGG1 |
| 3.2.2.23 | more |
base excision repair initiated by the enzyme is less effective in the first two days of growth and more effective later in stationary phase |
| 3.2.2.23 | DNA containing 8-oxoguanine residues + H2O |
best substrate |
