EC Number   |
Natural Substrates |
|---|
   3.1.4.54 | more |
recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview |
| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
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| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
biosynthetic enzyme of anandamide and its related bioactive congeners, the N-acylethanolamines |
| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
N-acylethanolamines constitute a family of endogenous bioactive lipids that includes arachidonoylethanolamide, i.e. anandamide, palmitoylethanolamide, and oleoylethanolamide. These lipids are formed from their respective N-acylated ethanolamine phospholipid precursor by the action of a phospholipase D enzyme, NAPE-PLD. The bioactive lipids may influence, amongst others: neuroinflammation, food intake, and oocyte implantation |
| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
the enzyme is involved in formation of N-acylethanolamines, membrane-derived lipids that are utilized as signaling molecules in the nervous system (e.g., the endocannabinoid anandamide) |
| 3.1.4.54 | N-arachidonoyl-phosphatidylethanolamine + H2O |
the enzyme is involved in the biosynthesis of anandamide, an endocannabinoid that belongs to the class of bioactive, long-chain N-acylethanolamines. Analysis of NAPE-PLD-deficient mice reveals the presence of NAPE-PLD independent pathways for the anandamide formation |
| 3.1.4.54 | N-arachidonoylphosphatidylethanolamine + H2O |
the enzyme is involved in the biosynthesis of anandamide (N-arachidonoylethanolamine). NAPE-PLD is responsible for the conversion of N-acylphosphatidylethanolamines to N-acylethanolamines in vivo, but other enzyme(s) or pathway(s) are also involved in it, especially in the formation of polyunsaturated N-acylethanolamines, including anandamide. Unlike classical neurotransmitters and neuropeptides, endocannabinoids are not stored in vesicles in the cell, rather they are produced on demand from membrane phospholipids by a series of intracellular enzymes and released from cells, followed by immediate action as signaling molecules. Binding of endocannabinoids as well as cannabinoids to cannabinoid receptors results in the decrease in intracellular cyclic AMP level and the activation of mitogen-activated protein kinase through the coupled Gi/o proteins. The activation of cannabinoid receptors modulates ion channels through Gi/o proteins, leading to the activation of A-type and inwardly rectifying potassium channels and the inhibition of N-type and P/Q-type calcium channels. The endocannabinoid system is involved in a broad range of physiological functions, such as emotion, cardiovascular regulation, energy metabolism, and reproduction, and in a growing number of pathophysiological conditions |
| 3.1.4.54 | N-arachidonoylphosphatidylethanolamine + H2O |
the enzyme is involved in the biosynthesis of anandamide, an endocannabinoid that belongs to the class of bioactive, long-chain N-acylethanolamines |
