EC Number   |
Natural Substrates |
|---|
   3.1.4.53 | 3',5'-cAMP + H2O |
- |
| 3.1.4.53 | 3',5'-cAMP + H2O |
DdPDE4 regulates intercellular cAMP during multicellular development |
| 3.1.4.53 | 3',5'-cAMP + H2O |
PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase |
| 3.1.4.53 | 3',5'-cAMP + H2O |
CpdA possesses 3',5'-cAMP phosphodiesterase activity in vitro |
| 3.1.4.53 | adenosine 3',5'-cyclic phosphate + H2O |
DdPDE4 is a unique membrane-bound phosphodiesterase with an extracellular catalytic domain regulating intercellular cAMP during multicellular development |
| 3.1.4.53 | adenosine 3',5'-cyclic phosphate + H2O |
PDE4B4 isoform may have a distinct functional role in regulating cAMP levels in specific cell types |
| 3.1.4.53 | adenosine 3',5'-cyclic phosphate + H2O |
both PDE8A and 8B hydrolyze cAMP with a very high affinity |
| 3.1.4.53 | adenosine 3',5'-cyclic phosphate + H2O |
determination of reaction rate and mechanism using computational modeling, quantum mechanical/molecular mechanical-free energy perturbation, QM/MM-FE, and QM/MM-Poisson-Boltzmann surface area, PBSA, calculations. The onQM/MMreaction-coordinate calculations including the protein environment of any PDE-catalyzed reaction system identifies a unique catalytic reaction mechanism, overview |
| 3.1.4.53 | more |
during development PDE4 is the major PDE |
| 3.1.4.53 | more |
PDE4 is a component of signaling pathways involved in the mediation of antidepressant activity |
