EC Number   |
Natural Substrates |
|---|
    3.1.4.4 | phosphatidylcholine + H2O |
- |
| 3.1.4.4 | phosphatidylethanolamine + H2O |
- |
| 3.1.4.4 | phosphatidylglycerol + H2O |
- |
| 3.1.4.4 | phosphatidylserine + H2O |
- |
| 3.1.4.4 | more |
5-[4-acridin-[9-ylamino]phenyl]-5-methyl-3-methylenedihydrofuran-2-one inhibits the formyl-Met-Leu-Phe-stimulated phospholipase D activity, mainly through the blockade of RhoA activation and degranulation |
| 3.1.4.4 | more |
ability of PLD-generated phosphatidic acid to control actin polymerization and the reciprocal ability of actin to specifically modulate PIP2-dependent PLD, PLDbeta, activity through direct interaction |
| 3.1.4.4 | more |
activation of phospholipase D by 8-Br-cAMP occurs through a pathway involving Src, Ras, and ERK in human endometrial stromal cells |
| 3.1.4.4 | more |
alpha-adrenoreceptor activation increases phospholipase D activity |
| 3.1.4.4 | phosphatidylcholine + H2O |
both phosphatidylcholine and phosphatidylethanolamine are substrates for phospholipase D in UMR-106 osteoblastic cells and can therefore be sources of phospholipid hydrolysis products for downstream signaling in osteoblast |
| 3.1.4.4 | more |
constitutive cation channel activity in ear artery myocytes is mediated by diacylglycerol which is generated by phosphatidylcholine-phospholipase D via phosphatidic acid which represents a novel activation pathway of cation channels in vascular myocytes |
