EC Number   |
Natural Substrates |
|---|
   3.1.4.1 | 3'-phosphohistidyl-linked tyrosyl-DNA phosphodiesterase I-DNA complex + H2O |
tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-histidyl bond formed between tyrosyl-DNA phosphodiesterase I and DNA |
| 3.1.4.1 | 3'-phosphotyrosyl-linked topoisomerase I-DNA complex + H2O |
tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-tyrosyl bond formed between DNA topoisomerase I and DNA |
| 3.1.4.1 | 5'-phosphotyrosyl-linked topoisomerase II-DNA complex + H2O |
tyrosyl-DNA phosphodiesterase I hydrolyzes the 5'phospho-tyrosyl bond formed between DNA topoisomerase II and DNA |
| 3.1.4.1 | ATP + H2O |
- |
| 3.1.4.1 | diadenosine polyphosphate + H2O |
phosphodiesterase can be considered as a catabolic enzyme |
| 3.1.4.1 | more |
the physiological function of PDE in plant cell is presumably the degradation of nucleic acids |
| 3.1.4.1 | more |
phosphodiesterase activity results in the cleavage of nucleotides from nucleic acids and thus may be involved in catabolism of extracellular DNA. Essential function may be to hydrolyze polyribo- and polydeoxyribonucleotides. The enzyme may be important in cell differentiation during carcinogenesis |
| 3.1.4.1 | more |
PC-1, PC-1 may take part in purine uptake for metabolic needs of cells |
| 3.1.4.1 | more |
PC-1, plasma-membrane-associated enzyme with nucleotide pyrophosphatase/phosphodiesterase I activity is probably involved in the clearance of extracellular nucleotides such as ATP and diadenosine polyphosphates |
| 3.1.4.1 | more |
enzyme might function as a modulating factor of platelet aggregation |
