EC Number   |
Natural Substrates |
|---|
   3.1.3.67 | 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O |
- |
| 3.1.3.67 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O |
dual-specific phosphatase |
| 3.1.3.67 | D-myo-phosphatidylinositol 3,4,5-trisphosphate + H2O |
- |
| 3.1.3.67 | more |
germline PTEN mutations are associated with several dominant growth disorders. The growth regulatory function is primarily mediated via its lipid phosphatase activity, which specifically reduces the cellular levels of phosphatidylinositol 3,4,5-trisphosphate. This activity antagonizes the effects of activated phosphatidylinositol 3-kinase in the nutritionally controlled insulin receptor pathway, thereby reducing protein synthesis and restraining cell and organismal growth, while also regulating other biological processes, such as fertility and ageing. PTEN also plays a role as specialized cytoskeletal regulator, which, for example, is involved in directional movement of some migratory cells and may be important in metastasis |
| 3.1.3.67 | more |
phosphatase-independent domains of PTEN markedly reduce the invasive potential of glioma cells, defining a structural role for PTEN that regulates cell motility distinct of the PKB/Akt pathway |
| 3.1.3.67 | more |
protein phosphatase activity may contribute to the cell cycle inhibitory and thereby tumor suppresive function of PTEN |
| 3.1.3.67 | more |
PTEN is a tumor suppressor inactivated in a variety of cancers such as glioblastoma and endometrial and prostate carcinoma. It acts as a phosphatidylinositol 3,4,5-triphosphate phosphatase antagonizing the activity of the phosphatidylinositol 3-OH kinase. The C-terminal region of PTEN contains secondary structure elements that are essential for the tumor-suppressor function of the protein |
| 3.1.3.67 | more |
PTEN might regulate cell-cycle progression by blocking activation of downstream targets of phosphatidylinositol 3-kinase such as the protooncogene Akt. PTEN is capable of inhibiting wild-type Akt kinase activity in cells |
| 3.1.3.67 | more |
PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein |
| 3.1.3.67 | more |
the enzyme plays a role in regulating the activity of the phosphatidylinositol 3-kinase pathway in malignant cells |
