EC Number   |
Natural Substrates |
|---|
   3.1.3.64 | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O |
- |
| 3.1.3.64 | 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O |
- |
| 3.1.3.64 | inositol 1,3-bisphosphate + H2O |
type I enzyme may regulate inositol 1,3-bisphosphate levels in cells and is designated inositol-polyphosphate 3-phosphatase |
| 3.1.3.64 | more |
enzyme deficiency is involved in XLMTM myopathies |
| 3.1.3.64 | more |
MTMR2, a phosphoinositide-3-phosphatase, associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-tooth disease |
| 3.1.3.64 | more |
MTMR6 is a negative regulator of the Ca2+-activated K+ channel KCa3.1 requiring MTMR6 enzyme activity with 1-phosphatidyl-1D-myo-inositol 3-phosphate, and the CC domain |
| 3.1.3.64 | more |
MTMR1, MTMR2, MTMR3, MTMR4, MTMR6, MTMR7, MTMR8 and Jumpy (also known as MTMR14), possess an active phosphatase domain, that specifically dephosphorylates 1-phosphatidyl-1D-myo-inositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate at position 3 on inositol ring |
| 3.1.3.64 | more |
PSD-95 interacts with MTMR2. MTMR2 is a 3-phosphatase specific for the phosphoinositides PI(3)P and PI(3,5)P2 |
| 3.1.3.64 | more |
PtdIns3P phosphatase binds protein DFCP1, which is associated with autophagosome formation, and DFCP1 localizes to the endoplasmic reticulum and omegasomes |
| 3.1.3.64 | more |
MTMR6 interacts with GDP-bound Rab1B via the GRAM domain |
