EC Number   |
Natural Substrates |
|---|
   3.1.3.53 | more |
involved in force regulation in smooth muscle, the relative expression of splice-in/splice-out myosin-targeting subunit isoforms determines the magnitude of agonist-induced force enhancement/Ca2+ sensitization |
| 3.1.3.53 | more |
two forms of SMP-I, the intact form and the catalytic subunit, may act in an opposite manner to regulate smooth muscle contraction in vivo |
| 3.1.3.53 | more |
pulmonary hypertension down-regulates pulmonary vascular MLCP expression, the maintenance of a high pulmonary vascular resistance may be secondary to abnormalities in tissue content and/or activity of MLCP |
| 3.1.3.53 | more |
involved in smooth muscle relaxation |
| 3.1.3.53 | more |
thrombin activates the Rho/Rho kinase pathway to inactivate myosin light chain phosphatase as part of a signaling network that controls myosin light chain phosphorylation and contraction in endothelial cells |
| 3.1.3.53 | more |
involved in the regulation of smooth muscle contraction, regulation of the MLCP activity |
| 3.1.3.53 | more |
together with myosin light chain kinase key regulatory enzyme of smooth muscle |
| 3.1.3.53 | more |
plays a key role in platelet function |
| 3.1.3.53 | more |
both gene products of protein phosphatase 1, PP1, (catalytic subunit of the myosin phosphatase) ppp1cba and ppp1cbb interact with Mypt1 (regulatory subunit of the myosin phosphatase) and assemble an active myosin phosphatase complex |
| 3.1.3.53 | more |
insulin stimulates the binding of MRIP (myosin phosphatase Rho-interacting protein) to MYPT1 in a dose- and time-dependent manner, as determined by immunoprecipitation |
