EC Number   |
Natural Substrates |
|---|
   3.1.25.1 | damaged DNA containing nucleotide cross-links + H2O |
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease |
| 3.1.25.1 | DNA + H2O |
- |
| 3.1.25.1 | DNA + H2O |
application of the enzyme to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, the enzyme influences DNA repair, mutagenesis, and cell signaling, enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation, overview |
| 3.1.25.1 | DNA + H2O |
first reaction step of the repair pathway to excise pyrimidine-dimers |
| 3.1.25.1 | more |
the enzyme initiates repair of deaminated bases in damaged DNA by making a nucleolytic incision one nucleotide away from the 3' side of the lesion |
| 3.1.25.1 | more |
the enzyme is involved in nucleotide excision repair of damaged DNA removing various types of bulky and distorting DNA adducts induced by UV radiation, process initiation is performed by UvrA, nicking by UvrB, which also recruits UvrC that catalyzes both the 3' and 5' incisions |
| 3.1.25.1 | more |
enzyme detects apurinic/apyrimidinic site base paired with adenine |
| 3.1.25.1 | more |
enzyme detects cyclobutane pyrimidine dimers (DNA lesions) caused by UVA irradiation |
| 3.1.25.1 | more |
UVA light directly generates a significant number of cyclobutane pyrimidine dimers as detected by a combined action of endonuclease IV and T4 endonuclease V |
| 3.1.25.1 | supercoiled DNA + H2O |
- |
