EC Number   |
Natural Substrates |
|---|
    3.1.2.6 | lactoylglutathione + H2O |
reaction is rate-limiting, methylglyoxal bypass of glycolysis |
| 3.1.2.6 | more |
the glyoxalase system may play an important role in the regulation of cell division and differentiation |
| 3.1.2.6 | more |
the enzyme catalyzes the rate limiting step of the glyoxalase pathway |
| 3.1.2.6 | more |
the enzyme participates in the detoxification of cytotoxic and mutagenic 2-oxoaldehydes |
| 3.1.2.6 | more |
OsglyII gene expression is stimulated within 15 min in response to various abiotic stresses as well as treatment with abscisic acid or salicylic acid |
| 3.1.2.6 | more |
the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. Accordingly, a specific responsive element is found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73. Upon overexpression, the cytosolic, but not the mitochondrial, GLX2 inhibits the apoptotic response of a cell to methylglyoxal, a by-product of glycolysis. Cells deficient in GLX2 are hypersensitive to methylglyoxal-induced apoptosis. A deficiency in GLX2 enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner |
| 3.1.2.6 | more |
catalytic process involves a water molecule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron |
| 3.1.2.6 | more |
GlxII belongs to the metallo-beta-lactamase superfamily of proteins, in which a zinc-binding motif is conserved |
| 3.1.2.6 | more |
glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids |
| 3.1.2.6 | more |
recombinant glyoxalase II hydrolyzes the trypanothione-thioesters of methylglyoxal, glyoxal and 4,5-dioxovalerate, substrates of the classical glyoxalase system, with high efficiency |
