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Results 1 - 10 of 26 > >>
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EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.418S-E pre-rRNA + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4miR-362-5p + H2O miR-362-5p is defined by DROSHA and DICER to 26 nt in length
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more physiological role of enzyme, recognition mechanisms that target mRNA for degradation
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more mRNA deadenylation by exoribonucleolytic activity of PARN is essential for embryogenesis and viability, deadenylation of mRNA is often the first and rate-limiting step in mRNA decay, loss of the enzyme affects poly(A) tail length distribution of only a select subset of embryonic transcripts
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more mRNA deadenylation by exoribonucleolytic activity of PARN is not essential for embryogenesis and viability
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more the enzyme plays an important role in the posttranscriptional maturation of mRNA poly(A) tails, factors involved in positive, e.g. Pan3p, and negative, e.g. Pbp1p, regulation, schematic model, overview
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more the poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis and 3' processing to export, Pab1p is essential, but several bypass suppressors exist, deletion leads to exosome-dependent retention at sites of transcription and inefficient nRNA release, e.g. of SSA4 mRNA, Pab1p and PAN interaction mechanism, overview
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more PARN interacts not only with the 3'-end of the mRNA but also with its 5'-end as PARN contains an RNA-recognition motif domain that specifically binds both the poly(A) tail and the 7-methylguanosine cap. The interaction of PARN with the 5'-cap of mRNAs stimulates the deadenylation activity and enhances the processivity of this reaction
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more PARN is a divalent metal ion-dependent 3'-exonuclease that specifically catalyzes the 3'-5'-degradation of the single-stranded poly(A) tail of mRNA with a free 3'-hydroxyl group
Display the word mapDisplay the reaction diagram Show all sequences 3.1.13.4more PARN is one of the major mammalian 3'-specific exoribonucleases involved in the degradation of the mRNA poly(A)-tail and it is also involved in the regulation of translation in early embryonic development, it is the key enzyme involved in the deadenylation of mRNA in a cap-dependent manner
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