EC Number   |
Natural Substrates |
|---|
   3.1.1.29 | diacetyl-lysyl-tRNALys + H2O |
- |
| 3.1.1.29 | more |
the enzyme plays a central role and is indispensable in Escherichia coli |
| 3.1.1.29 | more |
genetic interactions and the mechanism of peptidyl-tRNA drop-off of translating ribosomes leading to accumutaion of peptidyl-tRNA, overview |
| 3.1.1.29 | more |
the enzyme and its conserved active-site residues N12, H22 and D95 are essential for the viability of the bacteria |
| 3.1.1.29 | more |
the enzyme salvages tRNA from peptidyl-tRNA by hydrolyzing the ester link between the peptide and the 2'-or 3'-OH of the sugar at the end of tRNA, since accumulation of peptidyl-tRNA, due to drop-off of translating ribosomes, is toxic to the cell, overview |
| 3.1.1.29 | N-substituted aminoacyl-tRNA + H2O |
- |
| 3.1.1.29 | N-substituted aminoacyl-tRNA + H2O |
the enzyme or an element directly controlled by the enzyme, is the target for the lethal effect by bacterophage lambda |
| 3.1.1.29 | N-substituted aminoacyl-tRNA + H2O |
Pth recycles N-acetyl-aminoacyl tRNAs and peptidyl-tRNAs by cleaving the ester bond between tRNA and peptide |
| 3.1.1.29 | peptidyl-tRNA + H2O |
- |
| 3.1.1.29 | peptidyl-tRNA + H2O |
peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis |
