EC Number |
Natural Substrates |
---|
2.8.3.5 | succinyl-CoA + 3-hydroxybutyrate |
- |
2.8.3.5 | succinyl-CoA + a 3-oxo acid |
- |
2.8.3.5 | succinyl-CoA + a 3-oxo acid |
ketone bodies, produced mainly in the liver, are an important source of energy for extrahepatic tissues |
2.8.3.5 | succinyl-CoA + acetoacetate |
- |
2.8.3.5 | succinyl-CoA + acetoacetate |
ping-pong mechanism |
2.8.3.5 | succinyl-CoA + acetoacetate |
key enzyme for ketone body utilization, SCOT deficiency causes episodes of severe ketoacidosis |
2.8.3.5 | succinyl-CoA + acetoacetate |
essential enzyme in the metabolism of ketone bodies in higher animals, reaction via an enzyme-thioester intermediate |
2.8.3.5 | succinyl-CoA + acetoacetate |
involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production |
2.8.3.5 | succinyl-CoA + acetoacetate |
the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source |
2.8.3.5 | succinyl-CoA + acetoacetate |
ketolytic enzyme, uniquely involved in complete oxidation of ketone bodies |