EC Number   |
Natural Substrates |
|---|
   2.8.2.8 | 3'-phosphoadenylyl sulfate + (heparan sulfate)-glucosamine |
NDST-1 plays a role in lung development and repair following injury due to its influence on the activity of fibroblast growth factor |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine |
- |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
- |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
N-sulfated residues of heparan sulfate participate in the binding of this polymer to proteins as basic fibroblast growth factor |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
may be involved in biosynthesis of heparin and not of heparan sulfate |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
enzyme is present in embryonic tracheal tissue, which does not synthesize heparin |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
isozyme regulation, developmental importance in different tissues |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
the sulfation of the nitrogen of glucosamine in heparan sulfate is an obligatory step for subsequent epimerization of D-glucuronic to L-iduronic acid and of O-sulfation of the sugar chains |
| 2.8.2.8 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
cerebral hypoplasia and craniofacial defects are detected in mice lacking heparan sulfate Ndst1 gene function. Ndst1 is a crucial regulator of mammalian forebrain and facial development. Properly modified heparan sulfate is necessary for neuronal, glia and neural crest development |
