EC Number   |
Natural Substrates |
|---|
    2.7.8.15 | more |
alg7 mutants show diminished activity of GPT, reduced steady-state levels of lipid-linked oligosaccharides and hypoglycosylated carboxypeptidase Y. Mutants also lack mitochondrial DNA including the genes that encode the components of the respiratory machinery |
| 2.7.8.15 | UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate |
- |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
the enzyme catalyzes the committed step for N-linked glycosylation |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
first enzyme in the dolichol pathway of protein N-glycosylation. The all-trans-retinoic acid induction of the enzyme has a regulatory impact on the dolichol pathway |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
the enzyme initiates the dolichol pathway of protein N-glycosylation. A 2.5- to 4fold reduction in enzyme activity gives rise to distinct phenotypes, whose severity is inversely related to the level of enzyme activity. These phenotypes include hypersensitivity to tunicamycin, enlarged cell size, extensive aggregation, lack of typical stationary arrest and defective spore germination |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
the enzyme catalyzes the first step in the assembly of dolichol-linked oligosaccharides |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
enzyme activity, immunoreactive GPT, and GPT mRNA are modulated in parallel during development and stimulated to a similar extent by a combination of insulin, hydrocortisone and prolactin in mouse mammary gland |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
first enzyme of dolichol pathway |
| 2.7.8.15 | UDP-N-acetyl-D-glucosamine + dolichyl phosphate |
enzyme initiates the dolichol cycle for the biosynthesis of asparagine-linked glycoproteins |
