EC Number   |
Natural Substrates |
|---|
   2.7.8.11 | CDP-diacylglycerol + D-myo-inositol |
key step in lipid biosynthesis |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol |
- |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol |
formation of membrane phospholipids essential for the growth |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol |
enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol |
key enzyme in cell membrane biosynthesis |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol |
membrane lipid biosynthesis |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol |
enzyme plays a role in resynthesis of phosphatidylinositol during agonist-stimulated inositol-phospholipid metabolism |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol |
phosphatidylinositol synthase activity increased when zinc is depleted from the growth medium. Analysis of a zrt1DELTA zrt2DELTA mutant defective in plasma membrane zinc transport indicates that the cytoplasmic levels of zinc are responsible for the regulation of phosphatidylinositol synthase. Regulation of PIS1 gene expression by zinc depletion is mediated by the zinc-regulated transcription factor Zap1p. Direct in-teraction between glutathione S-transferase (GST)-Zap1p 687880 and a putative upstream activating sequence (UAS) zinc-responsive element in the PIS1 |
| 2.7.8.11 | more |
cytosolically made inositol and CDP-diacylglycerol can access the active site of the yeast PI synthase Pis1 from the cytosolic side |
