EC Number |
Natural Substrates |
---|
2.7.11.17 | ATP + a protein |
- |
2.7.11.17 | ATP + a protein |
the enzyme phosphorylates e.g. the synaptic vesicle-associated protein synapsin 1 and synapsin 2 |
2.7.11.17 | ATP + Akt |
the enzyme (CaMKK2) directly phosphorylates Akt at Thr308 |
2.7.11.17 | ATP + Blc10 |
Bcl10 is essential for antigen receptor-induced NF-kappaB activation, interleukin-2 production, and T-cell proliferation but is not required for TCR-induced tyrosine phosphorylation, calcium flux, or extracellular signal-regulated kinase activation |
2.7.11.17 | ATP + Ca2+/calmodulin-dependent protein kinase I |
the enzyme is a member of the CaMK cascade that mediates the response to intracellular Ca2+ elevation. Ca2+/calmodulin-dependent protein kinase kinase phosphorylates and activates Ca2+/calmodulin-dependent protein kinase I and Ca2+/calmodulin-dependent protein kinase IV, which directly activate transcription factors |
2.7.11.17 | ATP + Ca2+/calmodulin-dependent protein kinase IV |
the enzyme is a member of the CaMK cascade that mediates the response to intracellular Ca2+ elevation. Ca2+/calmodulin-dependent protein kinase kinase phosphorylates and activates Ca2+/calmodulin-dependent protein kinase I and Ca2+/calmodulin-dependent protein kinase IV, which directly activate transcription factors |
2.7.11.17 | ATP + Cabin1 |
a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, CaMKIV regulates nuclear export of Cabin1 during Ca2+-dependent T-cell activation, regulation overview |
2.7.11.17 | ATP + caldesmon |
- |
2.7.11.17 | ATP + caldesmon |
caldesmon plays a role in the regulation of smooth muscle contraction |
2.7.11.17 | ATP + cAMP response element-binding protein |
CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription |