EC Number   |
Natural Substrates |
|---|
   2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
- |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
enzyme is involved in the regulation of endosomal membrane traffic in mammalian cells |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
Stt4p activity is required for maintenance of vacuole morphology, cell wall integrity, and actin cytoskeleton organization. In contrast Pik1p is essential for normal secretion, Golgi and vacuole membrane dynamics and endocytosis |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
the enzyme is an integral component of the early signal transduction machinery during T-cell activation by concanavalin A and is actively regulated by protein tyrosine phosphorylation-dephosphorylation |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
exocytosis of insulin-containing secretory granules depends on phosphatidylinositol 4-kinase activity. Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
type III enzymes are responsible for distinct phosphoinositide pools |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
generation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the enzyme on synaptic vesicles may be the first step in the resynthesis of phosphatidylinositol 4,5-bisphosphate |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
phosphatidylinositol 4-kinase is a component of glucose transporter-containing vesicles. It may play a role in defining the fusogenic properties necessary to mediate membrane movement between the glucose transporter vesicles, plasma membranes and micosomes |
| 2.7.1.67 | ATP + 1-phosphatidyl-1D-myo-inositol |
regulation by Ca2+ may act as a negative feedback system |
