EC Number   |
Natural Substrates |
|---|
   2.7.1.154 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
- |
| 2.7.1.154 | ATP + phosphoinositides |
enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview |
| 2.7.1.154 | more |
TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase |
| 2.7.1.154 | more |
the class II phosphoinositide 3-kinase C2.alpha. is activated by clathrin and regulates clathrin-mediated membrane trafficking |
| 2.7.1.154 | more |
PI3K-C2alpha and PI3K-C2beta represent two downstream targets of the activated epidermal growth factor |
| 2.7.1.154 | more |
enzyme regulation, overview |
| 2.7.1.154 | more |
isozyme PI3K-C2alpha is a crucial survival factor for the cell |
| 2.7.1.154 | more |
the enzyme is regulated by intracellular signalling mechanisms |
| 2.7.1.154 | more |
the isozymes activate different signalling cascades via stem cell factor SCF in overexpressing cancer cell lines, e.g. association with c-Met, IGF-IR, regulation, class II PI3K C2beta blocks both protein kinase and small lung cell carcinoma in reponse to stem cell factor, polypeptide growth factors induce the recruitment of class IA and II isozymes to phosphotyrosine-containing signalling complexes, detailed overview |
| 2.7.1.154 | more |
the isozymes interact with and effect patterning of receptor signaling pathways, overview |
