EC Number   |
Natural Substrates |
|---|
    2.5.1.6 | ATP + L-methionine + H2O |
- |
| 2.5.1.6 | ATP + L-methionine + H2O |
a post-translational mechanism is involved in MAT regulation, the enzyme is down-regulated in pathological processes such as liver cirrhosis, overview |
| 2.5.1.6 | ATP + L-methionine + H2O |
an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine, S-adenosyl-L-methionine is also a key metabolite that regulates hepatocyte growth, death and differentiation, molecular mechanism, overview, abnormalities in MAT and decreased S-adenosyl-L-methionine levels occur in humans with alcoholic liver disease, chronic hepatic S-adenosyl-L-methionine deficiency can result in the spontaneous development of steatohepatitis and hepatocellular carcinoma, overview, hepatic S-adenosyl-L-methionine biosynthesis and methionine metabolism, overview |
| 2.5.1.6 | ATP + L-methionine + H2O |
aspartate family biosynthesis pathway and methionine metabolism, regulation, S-adenosyl-L-methionine activates threonine synthase expression and negatively regulates the transcript level of the cystathionine gamma-synthase, overview |
| 2.5.1.6 | ATP + L-methionine + H2O |
aspartate family biosynthesis pathway and methionine metabolism,regulation, S-adenosyl-L.methionine activates threonine synthase expression and negatively regulates the transcript level of the cystathionine gamma-synthase, overview |
| 2.5.1.6 | ATP + L-methionine + H2O |
biosynthesis of S-adenosyl-L-methionine |
| 2.5.1.6 | ATP + L-methionine + H2O |
biosynthesis of the key compound in the trans-methylation reactions |
| 2.5.1.6 | more |
genes in the S-box family are regulated by binding of S-adenosylmethionine to the 5' region of the mRNA of the regulated gene, SAM binding promotes a rearrangement of the RNA structure that results in premature termination of transcription in vitro and repression of expression of the downstream coding sequence, the S-box RNA element therefore acts as a SAM-binding riboswitch in vitro |
| 2.5.1.6 | ATP + L-methionine + H2O |
MAT activity controls cellular glutathione levels, polyamine synthesis and folate cycling |
| 2.5.1.6 | ATP + L-methionine + H2O |
methyl donor in transmethylation reactions and as propylamine donor for polyamine biosynthesis |
