EC Number   |
Natural Substrates |
|---|
    2.5.1.47 | cysteine + CN- |
involved in cyanide metabolism during seed germination |
| 2.5.1.47 | L-Cys + acetate |
involved in mobilization of sulfide from cysteine for Fe-S cluster formation, significance in vivo unclear |
| 2.5.1.47 | L-cysteine + dithiothreitol |
the side reaction of the enzyme seems to contribute massively to the total H2S release of higher plants at least at higher pH values |
| 2.5.1.47 | more |
enzyme is induced in leaves exposed to salt stress. The results suggest that the plant enzyme is responding to the salt stress by inducing cysteine biosynthesis as a protection against high ion concentrations |
| 2.5.1.47 | more |
model of a dynamic cysteine synthesis system with regulatory function |
| 2.5.1.47 | more |
the enzyme is induced by Al3+. Cysteine synthase may be a key player during Al response/adaptation in rice |
| 2.5.1.47 | more |
the enzyme is involved in tellurite resistance. OASS is not essential for cysteine biosynthesis |
| 2.5.1.47 | more |
cysteine synthase CysB is the only isoform of physiological importance in Aspergillus nidulans. Starvation-induced cysteine synthase activity is under control of cross-pathway regulation |
| 2.5.1.47 | more |
stopped-flow fluorescence spectroscopy is used to characterize the interaction of serine acetyltransferase with OASS and in the presence of the physiological regulators cysteine and bisulfide. Cysteine synthase assembly occurs via a two-step mechanism involving rapid formation of an encounter complex between the two enzymes, followed by a slow conformational change. The conformational change likely results from the closure of the active site of OASS upon binding of the serine acetyltransferase C-terminal peptide. Bisulfide stabilizes the cysteine synthase complex mainly by decreasing the back rate of the isomerization step. Cysteine, the product of the OASS reaction and a SAT inhibitor, slightly affects the kinetics of cysteine synthase formation leading to destabilization of the complex |
| 2.5.1.47 | more |
the enzyme shows H2S synthesizing activity, cysteine synthase activity and also L-3-cyanoalanine synthase activity, EC 4.4.1.9 |
