EC Number |
Natural Substrates |
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2.4.2.12 | more |
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis in tissues with a high demand for NAD+ |
2.4.2.12 | more |
NMPRTase is a crucial enzyme in the salvage pathway of NAD+ biosynthesis and has important functions in regulating NAD+ levels in cells undergoing substantial NAD+ turnover |
2.4.2.12 | more |
rate-limiting enzyme for NAD+ salvage from nicotinamide. Replicative senescence of smooth muscle cells is preceded by a marked decline in the expression and activity of Nampt. Nampt is a longevity protein that can add stress-resistant life to human smooth muscle cells by optimizing SIRT1-mediated p53 degradation |
2.4.2.12 | more |
visfatin mimics insulin signaling by binding to the insulin receptor with an affinity similar to that of insulin and does not share the binding site with insulin on the insulin receptor |
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate |
- |
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate |
first step in NAD synthesis from nicotinamide |
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate |
pre-B-cell colony enhancing factor |
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate |
key enzyme in the regulation of NAD+ biosynthesis from the natural precursor nicotinamide |
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate |
key enzyme in the regulation of NAD+ biosynthesis, regulates the silent regulator protein 2, i.e. Sir2, activity, the enzyme has a metabolic regulatory function by up- and downregulation of proteins, overview |
2.4.2.12 | nicotinamide + alpha-D-5-phosphoribosyl 1-diphosphate |
- |