EC Number   |
Natural Substrates |
|---|
    2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
- |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
essential enzyme for activation of 5-fluorouracil and its derivatives |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the enzyme is involved in the de novo biosynthesis of pyrimidine nucleotides, main enzyme involved in phosphoribosylation of 5-fluorouracil, an essential step that leads to tumor growth inhibition |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the enzyme is involved in the metabolism of 5-fluorouracil, a chemotherapeutic drug in treatment of solid cancers, major pathways of 5-fluorouracil metabolism, overview |
| 2.4.2.10 | more |
relationship between OPRT, antagonizing dihydropyrimidine dehydrogenase, and clinicopathologic features in cancer and treatment with 5-fluorouracil, relation of patients survival and enzyme activities after surgery, detailed overview |
| 2.4.2.10 | more |
the enzyme expression is weakly correlated to 5-fluorouracil sensitivity and apoptotic cell rate, overview |
| 2.4.2.10 | more |
the enzyme is associated with thymidylate synthase and dihydropyrimidine dehydrogenase in resectable colorectal cancer, overview, prognostic impact of the enzyme among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy, overview |
| 2.4.2.10 | orotate + 5-phospho-alpha-D-ribose 1-diphosphate |
- |
