EC Number |
Natural Substrates |
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2.4.1.38 | more |
enzyme activity might be involved in apoptotic pathway in hepatocarcinoma cells |
2.4.1.38 | more |
decreasing the expression of GalT V in glioma cells promotes apoptosis, inhibits the invasion and migration and the ability of tumor formation in vivo, and reduces the activation of AKT, the enzyme functions as a glioma growth activator, overview, contribution of GalT V in the activation of AKT and MAPK kinase, contribution of serum or EGF in the transcription regulation of the GalT V gene, overview |
2.4.1.38 | more |
downregulation of the enzyme inhibits CDK11(p58)-mediated apoptosis induced by cycloheximide, while ectopically expressed beta1,4-GT 1 increases CDK11p58-mediated apoptosis |
2.4.1.38 | more |
the cell surface enzyme promotes apoptosis by inhibiting the epidermal growth factor receptor pathway via inhibition of the autophosphorylation of epidermal growth factor receptor especially at Try 1068, mechanism, overview |
2.4.1.38 | more |
the enzyme is involved in regulation of carbohydrate composition of milk during lactation, endocrine enzyme regulation, overview |
2.4.1.38 | more |
the enzyme is part of the endoplasmic reticulum and Golgi glycosylation network, glycosyltransferase metabolism, overview |
2.4.1.38 | more |
tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview |
2.4.1.38 | more |
beta 1,4GalT V galactosylates the beta1,6-GlcNAc branch of N-glycans at the cell surface and of secreted glycoproteins, and functions as a positive regulator in glioma development, overview. As2O3-induced gioma cell apoptosis mechanism involves beta 1,4GalT V inhibition, overview |
2.4.1.38 | more |
beta-1,4-galactosylransferase participates in the synthesis of Galbeta1-4-GlcNac disaccharide unit of glycoconjugates, overview |
2.4.1.38 | more |
beta-1,4-GalT I is a type II membrane-bound glycoprotein, which occurs the plasma membrane of different types of cells where it serves as a cell surface adhesion molecule mediating various cell-cell and cell-matrix interactions such as sperm-egg binding, cell spreading, migration, and neurite outgrowth |