EC Number   |
Natural Substrates |
|---|
   2.4.1.222 | [Notch]-fucose + UDP-alpha-D-N-acetylglucosamine |
- |
| 2.4.1.222 | Notch + UDP-D-GlcNAc |
different enzyme forms, glycosylation of Notch modulates its binding to different receptors, e.g. binding to Serrate is decreased, while binding to Delta is enhanced, the enzyme thereby inhibits or activates signaling, Fringe proteins differentially modulate ligand-induced proteolysis of Notch1 |
| 2.4.1.222 | more |
Drosophila Fringe glycosyltransferase adds GlcNAc specifically to the O-fucose residues of Notch transmembrane proteins |
| 2.4.1.222 | Notch + UDP-D-GlcNAc |
enzyme completely inhibits binding of Notch protein to its serrate ligands by capping of O-fucose sites, regulation of enzyme activity via expression level in correspondance to the expression level of protein O-fucosyltransferase |
| 2.4.1.222 | Notch + UDP-D-GlcNAc |
enzyme modulates signaling through Notch receptors by modifying O-linked fucose on epidermal growth factor-like domains |
| 2.4.1.222 | Notch + UDP-D-GlcNAc |
enzyme plays a key role in the specification of boundaries during development by modulating the ability of Notch ligands to activate Notch receptors |
| 2.4.1.222 | Notch + UDP-D-GlcNAc |
Fringe and protein O-fucosyltransferase regulate Notch signaling via binding to cell surface Notch receptors, overview |
| 2.4.1.222 | more |
Fringe elongates O-fucose residues on EGF-like repeat 4 and 5 of Notch3. Fringe plays a role in CADASIL pathophysiology |
| 2.4.1.222 | [Notch]-fucose + UDP-alpha-D-N-acetylglucosamine |
Fringe genes encode beta-1,3-N-acetyl-glucosaminyltransferases, which elongate O-fucose on the EGF repeat of Notch and its ligands |
| 2.4.1.222 | more |
Fringe is required for the differentiation of polar cell precursors. Fringe is necessary for generating positional information in localizing a high-affinity interaction between Notch and its ligand Delta, even if a second ligand is not essential |
