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Results 1 - 10 of 22 > >>
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more ligand-receptor interactions and role of fringe glycosylation, regulation of signaling, overview, Fringe proteins do not influence the surface expression of Notch1
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more Fringe elongates O-fucose residues on EGF-like repeat 4 and 5 of Notch3. Fringe plays a role in CADASIL pathophysiology
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more Fringe is required for the differentiation of polar cell precursors. Fringe is necessary for generating positional information in localizing a high-affinity interaction between Notch and its ligand Delta, even if a second ligand is not essential
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more the glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more LFNG, Lunatic Fringe, and MFNG, Manic Fringe, transfer N-acetylglucosamine (GlcNAc) to O-fucose attached to EGF-like repeats of NOTCH receptors
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more O-GlcNAc is added to Notch by an enzymatic activity distinct from the well-known nuclear/cytoplasmic O-GlcNAc transferase, OGT, EC 2.4.1.255
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more Drosophila Fringe glycosyltransferase adds GlcNAc specifically to the O-fucose residues of Notch transmembrane proteins
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.222more the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch. Lfng inhibits activation of Notch1 and Notch4 in basal cells of the mouse prostate gland while enhancing Notch3 activation
Results 1 - 10 of 22 > >>