EC Number |
Natural Substrates |
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2.4.1.222 | more |
ligand-receptor interactions and role of fringe glycosylation, regulation of signaling, overview, Fringe proteins do not influence the surface expression of Notch1 |
2.4.1.222 | more |
Fringe elongates O-fucose residues on EGF-like repeat 4 and 5 of Notch3. Fringe plays a role in CADASIL pathophysiology |
2.4.1.222 | more |
Fringe is required for the differentiation of polar cell precursors. Fringe is necessary for generating positional information in localizing a high-affinity interaction between Notch and its ligand Delta, even if a second ligand is not essential |
2.4.1.222 | more |
the glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression |
2.4.1.222 | more |
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor |
2.4.1.222 | more |
LFNG, Lunatic Fringe, and MFNG, Manic Fringe, transfer N-acetylglucosamine (GlcNAc) to O-fucose attached to EGF-like repeats of NOTCH receptors |
2.4.1.222 | more |
O-GlcNAc is added to Notch by an enzymatic activity distinct from the well-known nuclear/cytoplasmic O-GlcNAc transferase, OGT, EC 2.4.1.255 |
2.4.1.222 | more |
Drosophila Fringe glycosyltransferase adds GlcNAc specifically to the O-fucose residues of Notch transmembrane proteins |
2.4.1.222 | more |
the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch |
2.4.1.222 | more |
the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch. Lfng inhibits activation of Notch1 and Notch4 in basal cells of the mouse prostate gland while enhancing Notch3 activation |