EC Number   |
Natural Substrates |
|---|
   2.4.1.214 | GDP-alpha-L-fucose + Galbeta1-4GlcNAc-R |
- |
| 2.4.1.214 | GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1-2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc |
- |
| 2.4.1.214 | GDP-beta-L-fucose + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc |
- |
| 2.4.1.214 | GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine |
- |
| 2.4.1.214 | more |
the core alpha1-3-fucosyltransferases are involved in the synthesis of glycans specific to plants and invertebrates which are known to be immunogenic and allergenic |
| 2.4.1.214 | more |
the enzyme functions in the synthesis of core alpha1-3-fucosylated complex-type glycans |
| 2.4.1.214 | more |
alpha1,3-fucosylation by FucT-VII is a step in the biosynthesis of Lewis X antigen, FucT-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1, phosphorylation of the Rb protein is involved, signaling pathway overview |
| 2.4.1.214 | more |
Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes |
| 2.4.1.214 | more |
FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability |
| 2.4.1.214 | more |
FucT-IV E- and P-selectin ligand precursors to give mature E- and P-selectin ligands, 3-alpha-fucosylates FucT-VII 3-alpha-fucosylates P-selectin ligand precursors to give mature P-selectin ligands that are essential for control of frequency of and all interaction related to leukocyte rolling, overview, FucT-IV and FucT-VII show overlapping activities in the immunosurveillance of the skin |
